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Article

Surface expression and channel function of TRPM8 are cooperatively controlled by transmembrane segments S3 and S4.

Pflugers Archiv : European journal of physiology - 1 Nov 2013

Kühn Frank J P, Winking Mathis, Kühn Cornelia, Hoffmann Daniel C, Lückhoff Andreas

Abstract excerpt

TRPM8 is a voltage-dependent cation channel additionally gated by cold temperatures, menthol, and icilin. Stimulation by the chemical agonists is at least in part mediated by a conserved sequence motif in transmembrane segment S3. Based on molecular dynamics simulation studies for TRPM8 a gating model was recently developed which predicts a direct electrostatic interaction between S3 and S4. Here, we performed...

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Source

Identifiers

PMID: 23708837
DOI: 10.1007/s00424-013-1302-4

Genes

TRPM8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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