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Article

Importance of a conserved sequence motif in transmembrane segment S3 for the gating of human TRPM8 and TRPM2.

PloS one - 1 Jan 2012

Winking Mathis, Hoffmann Daniel C, Kühn Cornelia, Hilgers Ralf-Dieter, Lückhoff Andreas, Kühn Frank J P

Abstract excerpt

For mammalian TRPM8, the amino acid residues asparagine-799 and aspartate-802 are essential for the stimulation of the channel by the synthetic agonist icilin. Both residues belong to the short sequence motif N-x-x-D within the transmembrane segment S3 highly conserved in the entire superfamily of voltage-dependent cation channels, among them TRPM8. Moreover, they are also conserved in the closely related TRPM2...

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Source

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Identifiers

PMID: 23185472
DOI: 10.1371/journal.pone.0049877
PMCID: PMC3503820

Genes

TRPM8
TRPM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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