Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signaling.

The American journal of pathology - 1 Jun 2013

Guijarro Maria V, Dahiya Sonika, Danielson Laura S, Segura Miguel F, Vales-Lara Frances M, Menendez Silvia, Popiolek Dorota, Mittal Khushbakhat, Wei Jian Jun, Zavadil Jiri, Cordon-Cardo Carlos, Pandolfi Pier Paolo, Hernando Eva

Abstract excerpt

Soft tissue sarcomas are a heterogeneous group of tumors associated with poor clinical outcome. Although a subset of soft tissue sarcomas is characterized by simple karyotypes and recurrent chromosomal translocations, the mechanisms driving cytogenetically complex sarcomas are largely unknown. Clinical evidence led us to partially inactivate Pten and Tp53 in the smooth muscle lineage of mice, which developed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Haploinsufficiency
Share to Leiomyosarcoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mesenchymal Stem Cells

Share to PTEN Phosphohydrolase

Share to Receptors, Notch

Share to Sarcoma

Share to Sarcoma, Experimental

Share to Soft Tissue Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 23708211
DOI: 10.1016/j.ajpath.2013.02.035
PMCID: PMC3668021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signaling.PMID 23708211Read ↗

The PTEN Tumor Suppressor Gene in Soft Tissue SarcomaSemantic proximity Read ↗

Genetic Screen in a Pre-Clinical Model of High-Grade Complex Karyotype Sarcoma Characterizes Drivers of Distinct Sarcoma Subtypes and Identifies New Therapeutic VulnerabilitiesSemantic proximity Read ↗

Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcomaSemantic proximity Read ↗

BMP2/SMAD pathway activation in JAK2/p53-mutant megakaryocyte/erythroid progenitors promotes leukemic transformation.Semantic proximity Read ↗

Constant p53 pathway inactivation in a large series of soft tissue sarcomas with complex genetics.Semantic proximity Read ↗

Animal models of soft-tissue sarcomaSemantic proximity Read ↗

Trp53 Haploinsufficiency Modifies EGFR-Driven Peripheral Nerve Sheath TumorigenesisSemantic proximity Read ↗

Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype.Semantic proximity Read ↗

p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTsSemantic proximity Read ↗

p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTsSemantic proximity Read ↗

You can win by losing: p53 mutations in rhabdomyosarcomas.Semantic proximity Read ↗

Histologic and Immunohistochemical Analyses of Soft Tissue Sarcomas From brca2-Mutant/ tp53-Mutant Zebrafish Are Consistent With Neural Crest (Schwann Cell) Origin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.