Article
Constant p53 pathway inactivation in a large series of soft tissue sarcomas with complex genetics.
The American journal of pathology - 1 Oct 2010
Pérot Gaëlle, Chibon Frédéric, Montero Audrey, Lagarde Pauline, de Thé Hugues, Terrier Philippe, Guillou Louis, Ranchère Dominique, Coindre Jean-Michel, Aurias Alain
Abstract excerpt
Alterations of the p53 pathway are among the most frequent aberrations observed in human cancers. We have performed an exhaustive analysis of TP53, p14, p15, and p16 status in a large series of 143 soft tissue sarcomas, rare tumors accounting for around 1% of all adult cancers, with complex genetics. For this purpose, we performed genomic studies, combining sequencing, copy number assessment, and expression...
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