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Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma

27 Mar 2015

Abstract excerpt

Liposarcoma (LPS) is a type of soft tissue sarcoma that mostly occurs in adults, and in humans is characterized by amplifications of MDM2 and CDK4. The molecular pathogenesis of this malignancy is still poorly understood and, therefore, we developed a mouse model with conditional inactivation of PTEN and p53 to investigate these pathways in the progression of the disease. We show that deletion of these two tumor...

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PMID: 25822339
DOI: 10.1038/cdd.2015.27

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