Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis.

doi:10.1038/ng.2517

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Article

Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis.

Nature genetics - 1 Feb 2013

Supply Philip, Marceau Michael, Mangenot Sophie, Roche David, Rouanet Carine, Khanna Varun, Majlessi Laleh, Criscuolo Alexis, Tap Julien, Pawlik Alexandre, Fiette Laurence, Orgeur Mickael, Fabre Michel, Parmentier Cécile, Frigui Wafa, Simeone Roxane, Boritsch Eva C, Debrie Anne-Sophie, Willery Eve, Walker Danielle, Quail Michael A, Ma Laurence, Bouchier Christiane, Salvignol Grégory, Sayes Fadel, Cascioferro Alessandro, Seemann Torsten, Barbe Valérie, Locht Camille, Gutierrez Maria-Cristina, Leclerc Claude, Bentley Stephen D, Stinear Timothy P, Brisse Sylvain, Médigue Claudine, Parkhill Julian, Cruveiller Stéphane, Brosch Roland

Abstract excerpt

Global spread and limited genetic variation are hallmarks of M. tuberculosis, the agent of human tuberculosis. In contrast, Mycobacterium canettii and related tubercle bacilli that also cause human tuberculosis and exhibit unusual smooth colony morphology are restricted to East Africa. Here, we sequenced and analyzed the whole genomes of five representative strains of smooth tubercle bacilli (STB) using Sanger...

Topics

Adaptation, Biological
Animals
Base Sequence
Cluster Analysis
Evolution, Molecular
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome, Bacterial

Genomics

Inverted Repeat Sequences

Lung

Mice

Mice, Inbred BALB C

Molecular Sequence Data

Mycobacterium tuberculosis

Phylogeny

Polymorphism, Single Nucleotide

Sequence Analysis, DNA

Species Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 23291586
DOI: 10.1038/ng.2517
PMCID: PMC3856870

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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