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Article

Structural Basis of PE_PGRS Polymorphism, a Tool for Functional Modulation.

Biomolecules - 10 May 2023

Kramarska Eliza, De Maio Flavio, Delogu Giovanni, Berisio Rita

Abstract excerpt

BACKGROUND: The mycobacterial PE_PGRS protein family is present only in pathogenic strains of the genus mycobacterium, such as Mtb and members of the MTB complex, suggesting a likely important role of this family in pathogenesis. Their PGRS domains are highly polymorphic and have been suggested to cause antigenic variations and facilitate pathogen survival. The availability of AlphaFold2.0 offered us a unique...

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PMID: 37238682
DOI: 10.3390/biom13050812
PMCID: PMC10216338

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