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Article

Comparative analysis of Mycobacterium tuberculosis pe and ppe genes reveals high sequence variation and an apparent absence of selective constraints.

PloS one - 1 Jan 2012

McEvoy Christopher R E, Cloete Ruben, Müller Borna, Schürch Anita C, van Helden Paul D, Gagneux Sebastien, Warren Robin M, Gey van Pittius Nicolaas C

Abstract excerpt

Mycobacterium tuberculosis complex (MTBC) genomes contain 2 large gene families termed pe and ppe. The function of pe/ppe proteins remains enigmatic but studies suggest that they are secreted or cell surface associated and are involved in bacterial virulence. Previous studies have also shown that some pe/ppe genes are polymorphic, a finding that suggests involvement in antigenic variation. Using comparative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22496726
DOI: 10.1371/journal.pone.0030593
PMCID: PMC3319526

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Comparative analysis of Mycobacterium tuberculosis pe and ppe genes reveals high sequence variation and an apparent absence of selective constraints.PMID 22496726Read ↗

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