Article
Classifications within molecular subtypes enables identification of BRCA1/BRCA2 mutation carriers by RNA tumor profiling.
PloS one - 1 Jan 2013
Larsen Martin J, Kruse Torben A, Tan Qihua, Lænkholm Anne-Vibeke, Bak Martin, Lykkesfeldt Anne E, Sørensen Kristina P, Hansen Thomas V O, Ejlertsen Bent, Gerdes Anne-Marie, Thomassen Mads
Abstract excerpt
Pathogenic germline mutations in BRCA1 or BRCA2 are detected in less than one third of families with a strong history of breast cancer. It is therefore expected that mutations still remain undetected by currently used screening methods. In addition, a growing number of BRCA1/2 sequence variants of unclear pathogen significance are found in the families, constituting an increasing clinical challenge. New methods...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.