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Article

Prevalence and Prognostic Role of BRCA1/2 Variants in Unselected Chinese Breast Cancer Patients.

PloS one - 1 Jan 2016

Zhong Xiaorong, Dong Zhengwei, Dong Hua, Li Jiayuan, Peng Zuxiang, Deng Ling, Zhu Xuehua, Sun Yun, Lu Xuesong, Shen Fuxiao, Su Xinying, Zhang Liying, Gu Yi, Zheng Hong

Abstract excerpt

BACKGROUND: The prevalence of BRCA1/2 variants in Chinese breast cancer patients varies among studies. Germline or somatic BRCA1/2 mutations are associated with sensitivity to poly(ADP-ribose) polymerase-1 inhibitors and DNA-damaging agents. We aimed to investigate the distribution of both somatic and germline BRCA1/2 variants in unselected Chinese breast cancer patients, and explore their roles in tumor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27257965
DOI: 10.1371/journal.pone.0156789
PMCID: PMC4892623

Genes

BRCA1
BRCA2

Provenance

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