Article
Etiology of gene expression-based subtypes of breast cancer in the Ghana Breast Health Study.
International journal of cancer - 1 Jun 2026
Hurson Amber N, Butler Ebonee N, Hamilton Alina M, Shah Khushali K, Sienso Bryan Aapentuo, Ocansey Grace Adjoa, Kunfah Sheba Mary Pognaa, Petershie Bernard, White Kaitlin E, Edusei Lawrence, Adjei Ernest, Dedey Florence, Vanderpuye Verna, Clegg-Lamptey Joe-Nat, Yarney Joel, Biritwum Richard, Nyarko Kofi M, Aitpillah Francis, Oppong Joseph K, Osei-Bonsu Ernest, Ansong Daniel, Awuah Baffour, Wiafe Beatrice Addai, Wiafe Seth, Brinton Louise, Ahearn Thomas U, Troester Melissa A, Figueroa Jonine D, Titiloye Nicolas, Garcia-Closas Montserrat, Abubakar Mustapha
Abstract excerpt
Breast cancers are heterogeneous and largely classified using immunohistochemistry of estrogen receptor expression. However, research suggests RNA-based subtyping, including intrinsic (luminal vs. non-luminal) and TP53-based subtypes, may offer additional etiologic insight. TP53 mutant tumors, often more aggressive and non-luminal, are common among women of African descent. We examined possible heterogeneity for...
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