Article
Comprehensive Proteomic Profiling-derived Immunohistochemistry-based Prediction Models for BRCA1 and BRCA2 Germline Mutation-related Breast Carcinomas.
The American journal of surgical pathology - 1 Sept 2018
Vos Shoko, Elias Sjoerd G, van der Groep Petra, Smolders Yvonne H, van Gils Carla H, van Diest Paul J
Abstract excerpt
Heredity, mostly due to BRCA germline mutations, is involved in 5% to 10% of all breast cancer cases. Potential BRCA germline mutation carriers may be missed following the current eligibility criteria for BRCA genetic testing. The purpose of this study was to, therefore, develop an immunohistochemistry-based model to predict likelihood of underlying BRCA1 and BRCA2 germline mutations in unselected female breast...
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