Article
RNA profiling reveals familial aggregation of molecular subtypes in non-BRCA1/2 breast cancer families.
BMC medical genomics - 31 Jan 2014
Larsen Martin J, Thomassen Mads, Tan Qihua, Lænkholm Anne-Vibeke, Bak Martin, Sørensen Kristina P, Andersen Mette Klarskov, Kruse Torben A, Gerdes Anne-Marie
Abstract excerpt
BACKGROUND: In more than 70% of families with a strong history of breast and ovarian cancers, pathogenic mutation in BRCA1 or BRCA2 cannot be identified, even though hereditary factors are expected to be involved. It has been proposed that tumors with similar molecular phenotypes also share similar underlying pathophysiological mechanisms. In the current study, the aim was to investigate if global RNA profiling...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.