Article
Breast Cancer Molecular Stratification: From Intrinsic Subtypes to Integrative Clusters.
The American journal of pathology - 1 Oct 2017
Russnes Hege G, Lingjærde Ole Christian, Børresen-Dale Anne-Lise, Caldas Carlos
Abstract excerpt
Breast carcinomas can be stratified into different entities based on clinical behavior, histologic features, and/or by biological properties. A classification of breast cancer should be based on underlying biology, which we know must be determined by the somatic genomic landscape of mutations. Moreover, because the latest generations of anticancer agents are founded on biological mechanisms, a detailed molecular...
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