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Article

Functional evaluation of genetic and environmental regulators of p450 mRNA levels.

PloS one - 1 Jan 2011

Wang Dazhi, Jiang Zhengwen, Shen Zhongyang, Wang Hui, Wang Beilan, Shou Weihua, Zheng Hong, Chu Xun, Shi Jinxiu, Huang Wei

Abstract excerpt

Variations in the activities of Cytochrome P450s are one of the major factors responsible for inter-individual differences in drug clearance rates, which may cause serious toxicity or inefficacy of therapeutic drugs. Various mRNA level is one of the key factors for different activity of the major P450 genes. Although both genetic and environmental regulators of P450 gene expression have been widely investigated,...

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Identifiers

PMID: 21998633
DOI: 10.1371/journal.pone.0024900
PMCID: PMC3187744

Genes

ACTB
GAPDH

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