Article
Cardiomyocyte specific adipose triglyceride lipase overexpression prevents doxorubicin induced cardiac dysfunction in female mice.
Heart (British Cardiac Society) - 1 Jul 2013
Nagendran Jeevan, Kienesberger Petra C, Pulinilkunnil Thomas, Zordoky Beshay N, Sung Miranda M, Kim Ty, Young Martin E, Dyck Jason R B
Abstract excerpt
OBJECTIVES: Anthracyclines such as doxorubicin are an effective class of antineoplastic agents. Despite its efficacy in the treatment of a variety of cancers, the clinical use of doxorubicin is limited by cardiac side effects. While it has been suggested that doxorubicin alters myocardial fatty acid metabolism, it is poorly understood whether this is the case and whether variations in myocardial triacylglycerol...
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