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Article

Decreased Soluble Guanylate Cyclase Contributes to Cardiac Dysfunction Induced by Chronic Doxorubicin Treatment in Mice.

Antioxidants & redox signaling - 1 Feb 2017

Vandenwijngaert Sara, Swinnen Melissa, Walravens Ann-Sophie, Beerens Manu, Gillijns Hilde, Caluwé Ellen, Tainsh Robert E, Nathan Daniel I, Allen Kaitlin, Brouckaert Peter, Bartunek Jozef, Scherrer-Crosbie Marielle, Bloch Kenneth D, Bloch Donald B, Janssens Stefan P, Buys Emmanuel S

Abstract excerpt

AIMS: The use of doxorubicin, a potent chemotherapeutic agent, is limited by cardiotoxicity. We tested the hypothesis that decreased soluble guanylate cyclase (sGC) enzyme activity contributes to the development of doxorubicin-induced cardiotoxicity. RESULTS: Doxorubicin administration (20 mg/kg, intraperitoneally [IP]) reduced cardiac sGC activity in wild-type (WT) mice. To investigate whether decreased sGC...

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Identifiers

PMID: 27505125
DOI: 10.1089/ars.2015.6542
PMCID: PMC5278809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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