Phosphoinositide 3-Kinase Gamma Inhibition Protects From Anthracycline Cardiotoxicity and Reduces Tumor Growth.

doi:10.1161/CIRCULATIONAHA.117.030352

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Article

Phosphoinositide 3-Kinase Gamma Inhibition Protects From Anthracycline Cardiotoxicity and Reduces Tumor Growth.

Circulation - 14 Aug 2018

Li Mingchuan, Sala Valentina, De Santis Maria Chiara, Cimino James, Cappello Paola, Pianca Nicola, Di Bona Anna, Margaria Jean Piero, Martini Miriam, Lazzarini Edoardo, Pirozzi Flora, Rossi Luca, Franco Irene, Bornbaum Julia, Heger Jacqueline, Rohrbach Susanne, Perino Alessia, Tocchetti Carlo G, Lima Braulio H F, Teixeira Mauro M, Porporato Paolo E, Schulz Rainer, Angelini Annalisa, Sandri Marco, Ameri Pietro, Sciarretta Sebastiano, Lima-Júnior Roberto César P, Mongillo Marco, Zaglia Tania, Morello Fulvio, Novelli Francesco, Hirsch Emilio, Ghigo Alessandra

Abstract excerpt

BACKGROUND: Anthracyclines, such as doxorubicin (DOX), are potent anticancer agents for the treatment of solid tumors and hematologic malignancies. However, their clinical use is hampered by cardiotoxicity. This study sought to investigate the role of phosphoinositide 3-kinase γ (PI3Kγ) in DOX-induced cardiotoxicity and the potential cardioprotective and anticancer effects of PI3Kγ inhibition. METHODS: Mice...

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PMID: 29348263
DOI: 10.1161/CIRCULATIONAHA.117.030352

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