Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants.

doi:10.1136/gutjnl-2012-304110

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Article

Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants.

Gut - 1 Mar 2014

Romanos Jihane, Rosén Anna, Kumar Vinod, Trynka Gosia, Franke Lude, Szperl Agata, Gutierrez-Achury Javier, van Diemen Cleo C, Kanninga Roan, Jankipersadsing Soesma A, Steck Andrea, Eisenbarth Georges, van Heel David A, Cukrowska Bozena, Bruno Valentina, Mazzilli Maria Cristina, Núñez Concepcion, Bilbao Jose Ramon, Mearin M Luisa, Barisani Donatella, Rewers Marian, Norris Jill M, Ivarsson Anneli, Boezen H Marieke, Liu Edwin, Wijmenga Cisca

Abstract excerpt

BACKGROUND: The majority of coeliac disease (CD) patients are not being properly diagnosed and therefore remain untreated, leading to a greater risk of developing CD-associated complications. The major genetic risk heterodimer, HLA-DQ2 and DQ8, is already used clinically to help exclude disease. However, approximately 40% of the population carry these alleles and the majority never develop CD. OBJECTIVE: We...

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Identifiers

PMID: 23704318
DOI: 10.1136/gutjnl-2012-304110
PMCID: PMC3933173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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