Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Improved HLA-based prediction of coeliac disease identifies two novel genetic interactions.

European journal of human genetics : EJHG - 1 Dec 2020

Erlichster Michael, Bedo Justin, Skafidas Efstratios, Kwan Patrick, Kowalczyk Adam, Goudey Benjamin

Abstract excerpt

Human Leucocyte Antigen (HLA) testing is useful in the clinical work-up of coeliac disease (CD) with high negative but low positive predictive value. We construct a genomic risk score (GRS) using HLA risk genotypes to improve CD prediction and guide exclusion criteria. Imputed HLA genotypes for five European CD case-control GWAS (n > 15,000) were used to construct and validate an interpretable HLA-based risk...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Alleles
Share to Celiac Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Genome-Wide Association Study

Share to HLA Antigens

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 32733071
DOI: 10.1038/s41431-020-0700-2
PMCID: PMC7785002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Improved HLA-based prediction of coeliac disease identifies two novel genetic interactions.PMID 32733071Read ↗

Improved HLA-based prediction of coeliac disease identifies two novel HLA risk modifiers, DQ6.2 and DQ7.3Semantic proximity Read ↗

Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants.Semantic proximity Read ↗

Genomic prediction of celiac disease targeting HLA-positive individualsSemantic proximity Read ↗

Genomic prediction of celiac disease targeting HLA-positive individualsSemantic proximity Read ↗

A single nucleotide polymorphism genetic risk score to aid diagnosis of coeliac disease: a pilot study in clinical care.Semantic proximity Read ↗

Combination Testing Using a Single MSH5 Variant alongside HLA Haplotypes Improves the Sensitivity of Predicting Coeliac Disease Risk in the Polish Population.Semantic proximity Read ↗

Accurate and robust genomic prediction of celiac disease using statistical learning.Semantic proximity Read ↗

Analysis of HLA and non-HLA alleles can identify individuals at high risk for celiac disease.Semantic proximity Read ↗

Phenome-wide association study in adult coeliac disease: role of HLA subtype.Semantic proximity Read ↗

Genetics in coeliac disease.Semantic proximity Read ↗

The genetics of celiac disease: A comprehensive review of clinical implications.Semantic proximity Read ↗

HLA in coeliac disease: Unravelling the complex genetics of a complex disorderSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.