Article

Improved HLA-based prediction of coeliac disease identifies two novel HLA risk modifiers, DQ6.2 and DQ7.3

2019-03-05

Abstract excerpt

<h4>Purpose</h4> Human Leukocyte Antigen (HLA) testing is useful in the clinical work-up of coeliac disease (CD), with high negative but low positive predictive value. We construct a genomic risk score (GRS) using HLA risk loci to improve CD prediction and guide exclusion criteria. <h4>Methods</h4> Imputed HLA genotypes for five European CD case-control GWAS (n>15,000) were used to construct and validate an HLA...

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Literature Corpus work: 49f6bb22-fc03-5456-8956-7571d8de089f
DOI: 10.1101/561308

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