Article
The role of hydromorphone and OPRM1 in postoperative pain relief with hydrocodone.
Pain physician - 1 Jan 2000
Boswell Mark V, Stauble M Elaine, Loyd Gary E, Langman Loralie, Ramey-Hartung Bronwyn, Baumgartner Richard N, Tucker William W, Jortani Saeed A
Abstract excerpt
BACKGROUND: Postoperative pain management remains a challenge for clinicians due to unpredictable patient responses to opioid therapy. Some of this variability may result from single nucleotide polymorphisms (SNPs) of the human opioid mu-1 receptor (OPRM1) that modify receptor binding or signal transduction. The OPRM1 variant with the highest frequency is the A118G SNP. However, previous studies have produced...
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