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Article

RUNX2-modifying enzymes: therapeutic targets for bone diseases

1 Aug 2020

Abstract excerpt

RUNX2 is a master transcription factor of osteoblast differentiation. RUNX2 expression in the bone and osteogenic front of a suture is crucial for cranial suture closure and membranous bone morphogenesis. In this manner, the regulation of RUNX2 is precisely controlled by multiple posttranslational modifications (PTMs) mediated by the stepwise recruitment of multiple enzymes. Genetic defects in RUNX2 itself or in...

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PMID: 32788656
DOI: 10.1038/s12276-020-0471-4

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