Article
Hydrogen sulfide restores a normal morphological phenotype in Werner syndrome fibroblasts, attenuates oxidative damage and modulates mTOR pathway.
Pharmacological research - 1 Aug 2013
Talaei F, van Praag V M, Henning R H
Abstract excerpt
Werner syndrome (WS) protein is involved in DNA repair and its truncation causes Werner syndrome, an autosomal recessive genetic disorder with a premature aging phenotype. WRN protein mutation is currently known as the primary cause of WS. In cultured WS fibroblasts, we found an increase in cytosolic aggregates and hypothesized that the phenotype is indirectly related to an excess activation of the mTOR...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.