Downregulation of the <scp>W</scp>erner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells

Abstract excerpt

The Werner syndrome protein (WRN) is a nuclear protein required for cell growth and proliferation. Loss-of-function mutations in the Werner syndrome gene are associated with the premature onset of age-related diseases. How loss of WRN limits cell proliferation and induces replicative senescence is poorly understood. Here, we show that WRN depletion leads to a striking metabolic shift that coordinately weakens the...

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