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Article

Hypocatalasemic Fibroblasts Accumulate Hydrogen Peroxide and Display Age‐Associated Pathologies

13 Oct 2005

Abstract excerpt

Human epidemiological studies point to an association of hypocatalasemia and an increased risk of age-related disease. Unfortunately, the cellular and molecular manifestations of hypocatalasemia are only poorly understood. In this analysis, we have extensively characterized hypocatalasemic human fibroblasts and report that they amass hydrogen peroxide and are oxidatively damaged. Protein and DNA alike are...

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PMID: 16445690
DOI: 10.1111/j.1600-0854.2005.00358.x

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