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Article

Multiple involvement of oxidative stress in Werner syndrome phenotype.

Biogerontology - 1 Jan 2005

Pagano Giovanni, Zatterale Adriana, Degan Paolo, d'Ischia Marco, Kelly Frank J, Pallardó Federico V, Kodama Seiji

Abstract excerpt

Werner syndrome is a genetic disease characterized by early ageing, excess cancer risk, high incidence of type II diabetes mellitus, early atherosclerosis, ocular cataracts, and osteoporosis. The protein encoded by the defective gene, WRN (WRNp) associates with three activities, that is, a RecQ DNA helicase, 3'-5'-exonuclease and ATPase activities. By highlighting the DNA helicase activity, a widespread consensus...

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Source

Identifiers

PMID: 16333757
DOI: 10.1007/s10522-005-2624-1

Genes

WRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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