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Article

Hprt activities and RNA phenotypes in 6-thioguanine resistant human T-lymphocytes.

Mutation research - 1 Apr 1993

Steen A M, Sahlén S, Hou S M, Lambert B

Abstract excerpt

The phenotypic effects of mutation in the hypoxanthine phosphoribosyltransferase (hprt) gene on hprt enzyme activity and hprt mRNA levels were studied in 6-thioguanine (TG) resistant human T-cell clones with various types of hprt mutation. The mean enzyme activity in 16 TG selected clones was less than 1% of the mean in unselected clones. The hprt mRNA levels, measured by a quantitative RNA/RNA solution...

Topics

Drug Resistance
Humans
Hypoxanthine Phosphoribosyltransferase
Mutation
Nucleic Acid Hybridization
Phenotype
RNA, Messenger
T-Lymphocytes
Thioguanine

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7681532
DOI: 10.1016/0027-5107(93)90185-i

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7681532-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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