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Article

Sequence-specific correction of genomic hypoxanthine-guanine phosphoribosyl transferase mutations in lymphoblasts by small fragment homologous replacement.

Oligonucleotides - 1 Feb 2010

Bedayat Babak, Abdolmohamadi Alireza, Ye Lin, Maurisse Rosalie, Parsi Hooman, Schwarz Jennifer, Emamekhoo Hamid, Nicklas Janice A, O'Neill J Patrick, Gruenert Dieter C

Abstract excerpt

Oligo/polynucleotide-based gene targeting strategies provide new options for achieving sequence-specific modification of genomic DNA and have implications for the development of new therapies and transgenic animal models. One such gene modification strategy, small fragment homologous replacement (SFHR), was evaluated qualitatively and quantitatively in human lymphoblasts that contain a single base substitution in...

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Identifiers

PMID: 19995283
DOI: 10.1089/oli.2009.0205
PMCID: PMC2948462

Genes

HPRT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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