Article
Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis.
JAMA - 5 Jun 2013
Peljto Anna L, Zhang Yingze, Fingerlin Tasha E, Ma Shwu-Fan, Garcia Joe G N, Richards Thomas J, Silveira Lori J, Lindell Kathleen O, Steele Mark P, Loyd James E, Gibson Kevin F, Seibold Max A, Brown Kevin K, Talbert Janet L, Markin Cheryl, Kossen Karl, Seiwert Scott D, Murphy Elissa, Noth Imre, Schwarz Marvin I, Kaminski Naftali, Schwartz David A
Abstract excerpt
IMPORTANCE: Current prediction models of mortality in idiopathic pulmonary fibrosis (IPF), which are based on clinical and physiological parameters, have modest value in predicting which patients will progress. In addition to the potential for improving prognostic models, identifying genetic and molecular features that are associated with IPF mortality may provide insight into the underlying mechanisms of disease...
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