MUC5B rs35705950 and its association with survival in Brazilian patients with idiopathic pulmonary fibrosis: A longitudinal cohort study.

doi:10.1371/journal.pone.0341661

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Article

MUC5B rs35705950 and its association with survival in Brazilian patients with idiopathic pulmonary fibrosis: A longitudinal cohort study.

PloS one - 1 Jan 2026

Rufino Rogerio, Faria Luana, Ribeiro-Alves Marcelo, Martinez Araujo Lucas Resende, Palermo Leonardo, Bessa Elizabeth, Rangel Bruno, Lopes Mariana Carneiro, Rufino Mariana Costa, Henrique da Costa Cláudia, de Souza Nogueira Jeane, Santos-Rebouças Cíntia Barros, Porto Luís Cristóvão

Abstract excerpt

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with heterogeneous clinical outcomes. The MUC5B promoter polymorphism (rs35705950) is the most consistent genetic factor associated with IPF susceptibility, but data from Latin American populations remain limited. METHODS: We conducted a longitudinal cohort study including 50 patients with IPF and 45 healthy controls,...

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PMID: 41610123
DOI: 10.1371/journal.pone.0341661
PMCID: PMC12854480

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MUC5B

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