Article
IDIOPATHIC PULMONARY FIBROSIS IS A COMPLEX GENETIC DISORDER.
Transactions of the American Clinical and Climatological Association - 1 Jan 2016
Schwartz David A
Abstract excerpt
Idiopathic pulmonary fibrosis (IPF) is a complex, heterogeneous genetic disorder that is associated with rare and common sequence variants in many genes (MUC5B, SFTPC, SFTPA2, RTEL1, TERT, and hTR), 11 novel loci, and multiple emerging epigenetic and transcriptional profiles. In the past 5 years, we have found that: 1) genetic risk variants play major and similar roles in the development of both familial and...
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