Article
Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.
The Lancet. Respiratory medicine - 1 Jun 2013
Noth Imre, Zhang Yingze, Ma Shwu-Fan, Flores Carlos, Barber Mathew, Huang Yong, Broderick Steven M, Wade Michael S, Hysi Pirro, Scuirba Joseph, Richards Thomas J, Juan-Guardela Brenda M, Vij Rekha, Han MeiLan K, Martinez Fernando J, Kossen Karl, Seiwert Scott D, Christie Jason D, Nicolae Dan, Kaminski Naftali, Garcia Joe G N
Abstract excerpt
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a devastating disease that probably involves several genetic loci. Several rare genetic variants and one common single nucleotide polymorphism (SNP) of MUC5B have been associated with the disease. Our aim was to identify additional common variants associated with susceptibility and ultimately mortality in IPF. METHODS: First, we did a three-stage genome-wide...
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