Effect of Muc5b promoter polymorphism on disease predisposition and survival in idiopathic interstitial pneumonias.

doi:10.1111/resp.12728

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Article

Effect of Muc5b promoter polymorphism on disease predisposition and survival in idiopathic interstitial pneumonias.

Respirology (Carlton, Vic.) - 1 May 2016

van der Vis Joanne J, Snetselaar Reinier, Kazemier Karin M, ten Klooster Liesbeth, Grutters Jan C, van Moorsel Coline H M

Abstract excerpt

BACKGROUND AND OBJECTIVE: A common polymorphism in the MUC5B gene (rs35705950) is associated with susceptibility to idiopathic pulmonary fibrosis (IPF) and familial interstitial pneumonia (FIP). We investigated predisposition of the MUC5B polymorphism to fibrotic interstitial pneumonias in Dutch Caucasian patient cohorts. Furthermore, we investigated the correlation between MUC5B genotype and survival in these...

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PMID: 26699835
DOI: 10.1111/resp.12728

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