Article
MUC5B rs35705950 minor allele associates with older age and better survival in idiopathic pulmonary fibrosis.
Respirology (Carlton, Vic.) - 1 May 2023
van der Vis Joanne J, Prasse Antje, Renzoni Elisabetta A, Stock Carmel J W, Caliskan Canay, Maher Toby M, Bonella Francesco, Borie Raphael, Crestani Bruno, Petrek Martin, Wuyts Wim A, Wind Anne E, Molyneaux Philip L, Grutters Jan C, van Moorsel Coline H M
Abstract excerpt
BACKGROUND AND OBJECTIVE: The minor T-allele of the MUC5B promoter polymorphism rs35705950 is strongly associated with idiopathic pulmonary fibrosis (IPF). However, conflicting results have been reported on the relationship between the MUC5B minor allele and survival and it is unknown whether a specific subgroup of IPF patients might benefit from MUC5B minor allele carriage. We investigated the association...
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