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Article

Prognostic role of MUC5B rs35705950 genotype in patients with idiopathic pulmonary fibrosis (IPF) on antifibrotic treatment.

Respiratory research - 1 Apr 2021

Biondini Davide, Cocconcelli Elisabetta, Bernardinello Nicol, Lorenzoni Giulia, Rigobello Chiara, Lococo Sara, Castelli Gioele, Baraldo Simonetta, Cosio Manuel G, Gregori Dario, Saetta Marina, Balestro Elisabetta, Spagnolo Paolo

Abstract excerpt

BACKGROUND: A common variant located in the promoter region of MUC5B (rs35705950) is the strongest risk factor for sporadic and familiar IPF, as well as a predictor of outcome. However, there are no data on the effect of MUC5B rs35705950 genotype on the prognosis of IPF patients on antifibrotic treatment. The aim of this study is to determine, in a phenotypically well-characterized population of patients with IPF...

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Identifiers

PMID: 33794872
DOI: 10.1186/s12931-021-01694-z
PMCID: PMC8017848

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