Article
Inheritance of low density lipoprotein subclass patterns in familial combined hyperlipidemia.
Arteriosclerosis (Dallas, Tex.) - 1 Jan 2000
Austin M A, Brunzell J D, Fitch W L, Krauss R M
Abstract excerpt
The inheritance of low density lipoprotein (LDL) subclass patterns was investigated in 234 members of seven large kindreds with familial combined hyperlipidemia (FCHL), a disorder characterized by elevated LDL cholesterol and/or triglyceride and increased coronary disease risk in families. Analysis of LDL subclasses by nondenaturing gradient gel electrophoresis showed a predominance of large, buoyant LDL...
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