Article
Linkage analysis of low-density lipoprotein subclass phenotypes and the apolipoprotein B gene.
Genetic epidemiology - 1 Jan 1991
LaBelle M, Austin M A, Rubin E, Krauss R M
Abstract excerpt
A common heritable phenotype has recently been identified which is characterized by a relative abundance of small, dense low-density lipoproteins (LDL), and mild elevations of plasma triglycerides and reductions in plasma high-density lipoproteins (HDL) cholesterol. This phenotype, designated LDL subclass phenotype B, has been associated with up to a three-fold increase in coronary disease risk. Complex...
Topics
- Adult
- Apolipoproteins B
- Base Sequence
- Chromosome Mapping
- Electrophoresis, Polyacrylamide Gel
- Female
- Genetic Linkage
- Humans
- Lipoproteins, LDL
- Lod Score
- Male
- Middle Aged