Article
A C-terminal truncated mutation of spr-3 gene extends lifespan in Caenorhabditis elegans.
Acta biochimica et biophysica Sinica - 1 Jul 2013
Yang Ping, Sun Ruilin, Yao Minghui, Chen Weidong, Wang Zhugang, Fei Jian
Abstract excerpt
The lifespan of Caenorhabditis elegans is determined by various genetic and environmental factors. In this paper, spr-3, a C. elegans homologous gene of the mammalian neural restrictive silencing factor (NRSF/REST), is reported to be an important gene regulating lifespan of C. elegans. A deletion mutation of spr-3, spr-3(ok2525), or RNAi inhibition of spr-3 expression led to the short lifespan phenotype in C....
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