Article
Neural-specific overexpression of drosophila plenty of SH3s (DPOSH) extends the longevity of adult flies.
Biogerontology - 1 Jan 2001
Seong K H, Matsuo T, Fuyama Y, Aigaki T
Abstract excerpt
Extended longevity mutants are extremely useful to understand the molecular mechanism of longevity determination. Here we report identification and characterization of the Drosophila Plenty of SH3s (DPOSH) gene, a candidate that might be associated with the extended longevity phenotype. DPOSH encodes a protein containing a RING finger domain and four SH3 domains. We showed that neural-specific overexpression of...
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