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Article

Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1.

The EMBO journal - 1 Nov 2002

Eimer S, Lakowski B, Donhauser R, Baumeister R

Abstract excerpt

Presenilins are part of a protease complex that is responsible for the intramembraneous cleavage of the amyloid precursor protein involved in Alzheimer's disease and of Notch receptors. In Caenorhabditis elegans, mutations in the presenilin sel-12 result in a highly penetrant egg-laying defect. spr-5 was identified as an extragenic suppressor of the sel-12 mutant phenotype. The SPR-5 protein has similarity to the...

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Source

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Identifiers

PMID: 12411496
DOI: 10.1093/emboj/cdf561
PMCID: PMC131058

Genes

SPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1.PMID 12411496Read ↗

Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans.Semantic proximity Read ↗

spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily.Semantic proximity Read ↗

SEL-5, a serine/threonine kinase that facilitates lin-12 activity in Caenorhabditis elegans.Semantic proximity Read ↗

lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development in C. elegans.Semantic proximity Read ↗

Two suppressors of sel-12 encode C2H2 zinc-finger proteins that regulate presenilin transcription in Caenorhabditis elegans.Semantic proximity Read ↗

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling.Semantic proximity Read ↗

UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in Caenorhabditis elegans.Semantic proximity Read ↗

Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin.Semantic proximity Read ↗

The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilinsSemantic proximity Read ↗

Mutations in genes involved in nonsense mediated decay ameliorate the phenotype of sel-12 mutants with amber stop mutations in Caenorhabditis elegans.Semantic proximity Read ↗

Presenilin is required for proper morphology and function of neurons in C. elegans.Semantic proximity Read ↗

Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling.Semantic proximity Read ↗

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