Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reserpine requires the D2-type receptor, dop-3, and the exoribonuclease, eri-1, to extend the lifespan in C. elegans.

Journal of biosciences - 1 Dec 2016

Saharia Kopal, Kumar Ranjeet, Gupta Kuldeep, Mishra Shrilekha, Subramaniam Jamuna R

Abstract excerpt

Lifespan extension is an all systems encompassing event. Involvement of reduced insulin/IGF1 signalling is well worked out, first in the model organism Caenorhbaditis elegans followed by other systems including humans. But the role of neuronal component in lifespan extension is not well understood due to the refractory nature of neurons to small RNA interference (sRNAi) in C. elegans. Earlier, we have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior, Animal
Share to Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caenorhabditis elegans Proteins

Share to Exoribonucleases

Share to GTP-Binding Protein alpha Subunits, Gi-Go

Share to Longevity

Share to Multidrug Resistance-Associated Proteins

Share to Receptors, Dopamine D2

Source

Identifiers

PMID: 27966489
DOI: 10.1007/s12038-016-9652-7

Genes

IGF1
JUN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reserpine requires the D2-type receptor, dop-3, and the exoribonuclease, eri-1, to extend the lifespan in C. elegans.PMID 27966489Read ↗

Dopamine D1- and D2-like receptors oppositely regulate lifespan via a dietary restriction mechanism in Caenorhabditis elegansSemantic proximity Read ↗

Rilmenidine mimics caloric restriction via the nischarin I1-imidazoline receptor to extend lifespan in <i>C. elegans</i>Semantic proximity Read ↗

Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegansSemantic proximity Read ↗

Systemic RNA interference-defective (SID) genes modulate dopaminergic neurodegeneration in <i>C. elegans</i>Semantic proximity Read ↗

Haloperidol Interactions with the dop-3 Receptor in Caenorhabditis elegans.Semantic proximity Read ↗

Gαq Mediates Clozapine Effects in <i>Caenorhabditis</i> elegansSemantic proximity Read ↗

A small-molecule screen in C. elegans yields a new calcium channel antagonist.Semantic proximity Read ↗

Rilmenidine is a calorie restriction mimetic that improves survival and indicators of healthy ageing in C. elegans via a novel IRAS ortholog, f13e9.1Semantic proximity Read ↗

6-OHDA-induced dopaminergic neurodegeneration in <i>C. elegans</i> is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33Semantic proximity Read ↗

Ursolic acid ameliorates stress and reactive oxygen species in C. elegans knockout mutants by the dopamine Dop1 and Dop3 receptors.Semantic proximity Read ↗

Integrated Regulation of Dopaminergic and Epigenetic Effectors of Neuroprotection in Parkinson’s Disease ModelsSemantic proximity Read ↗

Cannabinoids Activate the Insulin Pathway to Modulate Mobilization of Cholesterol in <i>C. elegans</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.