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Article

The pre-synaptic Munc13-1 binds alcohol and modulates alcohol self-administration in Drosophila.

Journal of neurochemistry - 1 Sept 2013

Das Joydip, Xu Shiyu, Pany Satyabrata, Guillory Ashley, Shah Vrutant, Roman Gregg W

Abstract excerpt

Munc13-1 is a pre-synaptic active-zone protein essential for neurotransmitter release and involved in pre-synaptic plasticity in brain. Ethanol, butanol, and octanol quenched the intrinsic fluorescence of the C1 domain of Munc13-1 with EC₅₀ s of 52 mM, 26 mM, and 0.7 mM, respectively. Photoactive azialcohols photolabeled Munc13-1 C1 exclusively at Glu-582, which was identified by mass spectrometry. Mutation of...

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Identifiers

PMID: 23692447
DOI: 10.1111/jnc.12315
PMCID: PMC3766433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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