Article
KCNQ channels show conserved ethanol block and function in ethanol behaviour.
PloS one - 1 Jan 2012
Cavaliere Sonia, Gillespie John M, Hodge James J L
Abstract excerpt
In humans, KCNQ2/3 channels form an M-current that regulates neuronal excitability, with mutations in these channels causing benign neonatal familial convulsions. The M-current is important in mechanisms of neural plasticity underlying associative memory and in the response to ethanol, with KCNQ controlling the release of dopamine after ethanol exposure. We show that dKCNQ is broadly expressed in the nervous...
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