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Target Cell APOBEC3C Can Induce Limited G-to-A Mutation in HIV-1

23 Oct 2007

Abstract excerpt

The evolutionary success of primate lentiviruses reflects their high capacity to mutate and adapt to new host species, immune responses within individual hosts, and, in recent years, antiviral drugs. APOBEC3G (A3G) and APOBEC3F (A3F) are host cell DNA-editing enzymes that induce extensive HIV-1 mutation that severely attenuates viral replication. The HIV-1 virion infectivity factor (Vif), expressed in vivo,...

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PMID: 17967058
DOI: 10.1371/journal.ppat.0030153

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Target Cell APOBEC3C Can Induce Limited G-to-A Mutation in HIV-1PMID 17967058Read ↗

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The host restriction factor APOBEC3G and retroviral Vif protein coevolve due to ongoing genetic conflict.Semantic proximity Read ↗

Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n.Semantic proximity Read ↗

APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNA.Semantic proximity Read ↗

Extremely High Mutation Rate of HIV-1 In VivoSemantic proximity Read ↗

Convergence and divergence in the evolution of the APOBEC3G-Vif interaction reveal ancient origins of simian immunodeficiency viruses.Semantic proximity Read ↗

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Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replication.Semantic proximity Read ↗

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