Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Function of resistance conferring Plasmodium falciparum chloroquine resistance transporter isoforms.

Biochemistry - 18 Jun 2013

Baro Nicholas K, Callaghan Paul S, Roepe Paul D

Abstract excerpt

The function of Plasmodium falciparum chloroquine resistance transporter (PfCRT) can be quantified using a Saccharomyces cerevisiae model system [Baro, N. K., Pooput, C., and Roepe, P. D. (2011) Biochemistry 50, 6701-6710]. We further optimized this system to distinguish PfCRT isoforms found in P. falciparum strains and isolates from across the globe. We created and expressed 13 naturally occurring pfcrt alleles...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemistry, Pharmaceutical
Share to Chloroquine
Share to Drug Design

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Galactose

Share to Inhibitory Concentration 50

Share to Plasmodium falciparum

Share to Protein Isoforms

Share to Protozoan Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23688277
DOI: 10.1021/bi400557x
PMCID: PMC3703759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Function of resistance conferring Plasmodium falciparum chloroquine resistance transporter isoforms.PMID 23688277Read ↗

Functional Comparison of 45 Naturally Occurring Isoforms of the Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT).Semantic proximity Read ↗

Altered Drug Transport by Plasmodium falciparum Chloroquine Resistance Transporter Isoforms Harboring Mutations Associated with Piperaquine Resistance.Semantic proximity Read ↗

pfcrt is more than the Plasmodium falciparum chloroquine resistance gene: a functional and evolutionary perspective.Semantic proximity Read ↗

PfCRT and its role in antimalarial drug resistance.Semantic proximity Read ↗

PfCRT-mediated drug transport in malarial parasites.Semantic proximity Read ↗

Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology.Semantic proximity Read ↗

Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations.Semantic proximity Read ↗

Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter.Semantic proximity Read ↗

The antimalarial drug resistance protein Plasmodium falciparum chloroquine resistance transporter binds chloroquine.Semantic proximity Read ↗

Analysis of the antimalarial drug resistance protein Pfcrt expressed in yeast.Semantic proximity Read ↗

Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum.Semantic proximity Read ↗

Metabolic QTL Analysis Links Chloroquine Resistance in Plasmodium falciparum to Impaired Hemoglobin CatabolismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.