Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered Drug Transport by Plasmodium falciparum Chloroquine Resistance Transporter Isoforms Harboring Mutations Associated with Piperaquine Resistance.

Biochemistry - 14 Jul 2020

Riegel Bryce, Roepe Paul D

Abstract excerpt

Patterns of multiple amino acid substitutions in the Plasmodium falciparum chloroquine resistance transporter (PfCRT, UniProtKB Q8IBZ9) have previously been shown to mediate chloroquine resistance in P. falciparum malarial parasites. Recent reports suggest that novel mutations in PfCRT may mediate resistance to piperaquine (PPQ), which is used extensively as a partner drug in one prominent artemisinin combination...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimalarials
Share to Cell Culture Techniques
Share to Chloroquine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance

Share to Malaria, Falciparum

Share to Plasmodium falciparum

Share to Protozoan Proteins

Share to Quinolines

Source

Identifiers

PMID: 32589406
DOI: 10.1021/acs.biochem.0c00247

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered Drug Transport by Plasmodium falciparum Chloroquine Resistance Transporter Isoforms Harboring Mutations Associated with Piperaquine Resistance.PMID 32589406Read ↗

Functional Comparison of 45 Naturally Occurring Isoforms of the Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT).Semantic proximity Read ↗

PfCRT and its role in antimalarial drug resistance.Semantic proximity Read ↗

Function of resistance conferring Plasmodium falciparum chloroquine resistance transporter isoforms.Semantic proximity Read ↗

pfcrt is more than the Plasmodium falciparum chloroquine resistance gene: a functional and evolutionary perspective.Semantic proximity Read ↗

Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics.Semantic proximity Read ↗

Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations.Semantic proximity Read ↗

Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages.Semantic proximity Read ↗

PfCRT mutations conferring piperaquine resistance in falciparum malaria shape the kinetics of quinoline drug binding and transport.Semantic proximity Read ↗

A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine.Semantic proximity Read ↗

PfCRT-mediated drug transport in malarial parasites.Semantic proximity Read ↗

Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents.Semantic proximity Read ↗

Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.