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Article

Hypocrea jecorina cellobiohydrolase I stabilizing mutations identified using noncontiguous recombination.

ACS synthetic biology - 20 Dec 2013

Smith Matthew A, Bedbrook Claire N, Wu Timothy, Arnold Frances H

Abstract excerpt

Noncontiguous recombination (NCR) is a method to identify pieces of structure that can be swapped among homologous proteins to create new, chimeric proteins. These "blocks" are encoded by elements of sequence that are not necessarily contiguous along the polypeptide chain. We used NCR to design a...

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PMID: 23688124
DOI: 10.1021/sb400010m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23688124-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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