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Article

Stabilizing proteins from sequence statistics: the interplay of conservation and correlation in triosephosphate isomerase stability.

Journal of molecular biology - 20 Jul 2012

Sullivan Brandon J, Nguyen Tran, Durani Venuka, Mathur Deepti, Rojas Samantha, Thomas Miriam, Syu Trixy, Magliery Thomas J

Abstract excerpt

Understanding the determinants of protein stability remains one of protein science's greatest challenges. There are still no computational solutions that calculate the stability effects of even point mutations with sufficient reliability for practical use. Amino acid substitutions rarely increase the stability of native proteins; hence, large libraries and high-throughput screens or selections are needed to...

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Identifiers

PMID: 22555051
DOI: 10.1016/j.jmb.2012.04.025
PMCID: PMC3578383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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