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Article

The CXXC motif is more than a redox rheostat.

The Journal of biological chemistry - 28 Sept 2007

Quan Shu, Schneider Irmhild, Pan Jonathan, Von Hacht Annekathrin, Bardwell James C A

Abstract excerpt

The CXXC active-site motif of thiol-disulfide oxidoreductases is thought to act as a redox rheostat, the sequence of which determines its reduction potential and functional properties. We tested this idea by selecting for mutants of the CXXC motif in a reducing oxidoreductase (thioredoxin) that c...

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Identifiers

PMID: 17675287
DOI: 10.1074/jbc.M705291200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17675287-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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